Implementation of proteomic biomarkers: making it work
Identifieur interne : 005661 ( Main/Exploration ); précédent : 005660; suivant : 005662Implementation of proteomic biomarkers: making it work
Auteurs : Harald Mischak [Royaume-Uni, Allemagne] ; John P. A. Ioannidis [Grèce, États-Unis] ; Angel Argiles [France] ; Teresa K. Attwood [Royaume-Uni] ; Erik Bongcam-Rudloff [Suède] ; Mark Broenstrup [Allemagne] ; Aristidis Charonis [Grèce] ; George P. Chrousos [Grèce] ; Christian Delles [Royaume-Uni] ; Anna Dominiczak [Royaume-Uni] ; Tomasz Dylag [Belgique] ; Jochen Ehrich [Allemagne] ; Jesus Egido [Espagne] ; Peter Findeisen [Allemagne] ; Joachim Jankowski [Allemagne] ; Robert W. Johnson [États-Unis] ; Bruce A. Julien [États-Unis] ; Tim Lankisch [Allemagne] ; Hing Y. Leung [Royaume-Uni] ; David Maahs [États-Unis] ; Fulvio Magni [Italie] ; Michael P. Manns [Allemagne] ; Efthymios Manolis [Royaume-Uni] ; Gert Mayer [Autriche] ; Gerjan Navis [Pays-Bas] ; Jan Novak [États-Unis] ; Alberto Ortiz [Espagne] ; Frederik Persson [Danemark] ; Karlheinz Peter [Australie] ; Hans H. Riese [Espagne] ; Peter Rossing [Danemark] ; Naveed Sattar [Royaume-Uni] ; Goce Spasovski [Macédoine (pays)] ; Visith Thongboonkerd [Thaïlande] ; Raymond Vanholder [Belgique] ; Joost P. Schanstra [France] ; Antonia Vlahou [Grèce]Source :
- European Journal of Clinical Investigation [ 0014-2972 ] ; 2012-09.
Descripteurs français
- Wicri :
- topic : Diabète, Assurance maladie, Sciences de la vie.
English descriptors
- KwdEn :
- Abbott park, Actual implementation, Aghia sophia hospital, Agricultural sciences, Appl, Appropriate specimens, Athens university, Beatson institute, Biobanks, Biomarker, Biomarker community, Biomarker discovery, Biomarker evaluation, Biomarkers, Biomedical research foundation, Cancer biomarkers, Cancer research, Cell proteomics, Centre groningen, Childhood diabetes, Chronic kidney disease, Clin, Clin cancer, Clin chem, Clinical adoption, Clinical application, Clinical chemistry, Clinical implementation, Clinical investigation, Clinical investigation journal foundation implementation, Clinical proteomics, Clinical trials, Clinical validity, Collaborative projects, Colorado denver, Computer science, Current situation, Data analysis, Deutschland gmbh frankfurt, Diabetes, Diabetes mellitus, Diabetic nephropathy, Different categories, Drug development, Early detection research network, Early prevention, Endpoint, European biobanks, European commission, European journal, European kidney, European medicines agency, Everyday practice, Experimental medicine, Foreseeable future, Former yugoslav republic, Funding, Garscube estate, Ghent university hospital, Glasgow, Hannover, Hard endpoint, Hard endpoints, Health carlos, Health economists, Health insurance, Health research, Implementation, Implementation process, Initial discovery, Internal medicine, Intervention study, Interventional trials, Ioannidis, Ioannina school, Jimenez autonoma university, Last decade, Life sciences, Mahidol university, Many years, Medical faculty, Medical practice, Medical sciences, Medical university, Medizinische klinik, Metabolic disease, Microvascular outcomes, Mischak, Molecular epidemiology unit, Montpellier cedex, Multidisciplinary panel, Natl cancer inst, Ndings, Patient groups, Performance characteristics, Personalised medicine, Possible solutions, Proteomic, Proteomic biomarkers, Proteomics, Proteomics clin appl, Randomised trials, Recherche medicale, Regulatory agencies, Renal, Renal disease, Research centre, Research priorities, Siriraj hospital, Stanford, Stanford university school, Stichting european society, Successful biomarker discovery, Successful implementation, Surrogate, Surrogate endpoints, Surrogate parameter, Swedish university, Therapeutic intervention, Uncertain path, Universitatsklinikum mannheim, Universite toulouse, Uppsala university, Urine proteomics cost action, Useful biomarkers, Valid biomarkers, Validation, Validation processes.
- Teeft :
- Abbott park, Actual implementation, Aghia sophia hospital, Agricultural sciences, Appl, Appropriate specimens, Athens university, Beatson institute, Biobanks, Biomarker, Biomarker community, Biomarker discovery, Biomarker evaluation, Biomarkers, Biomedical research foundation, Cancer biomarkers, Cancer research, Cell proteomics, Centre groningen, Childhood diabetes, Chronic kidney disease, Clin, Clin cancer, Clin chem, Clinical adoption, Clinical application, Clinical chemistry, Clinical implementation, Clinical investigation, Clinical investigation journal foundation implementation, Clinical proteomics, Clinical trials, Clinical validity, Collaborative projects, Colorado denver, Computer science, Current situation, Data analysis, Deutschland gmbh frankfurt, Diabetes, Diabetes mellitus, Diabetic nephropathy, Different categories, Drug development, Early detection research network, Early prevention, Endpoint, European biobanks, European commission, European journal, European kidney, European medicines agency, Everyday practice, Experimental medicine, Foreseeable future, Former yugoslav republic, Funding, Garscube estate, Ghent university hospital, Glasgow, Hannover, Hard endpoint, Hard endpoints, Health carlos, Health economists, Health insurance, Health research, Implementation, Implementation process, Initial discovery, Internal medicine, Intervention study, Interventional trials, Ioannidis, Ioannina school, Jimenez autonoma university, Last decade, Life sciences, Mahidol university, Many years, Medical faculty, Medical practice, Medical sciences, Medical university, Medizinische klinik, Metabolic disease, Microvascular outcomes, Mischak, Molecular epidemiology unit, Montpellier cedex, Multidisciplinary panel, Natl cancer inst, Ndings, Patient groups, Performance characteristics, Personalised medicine, Possible solutions, Proteomic, Proteomic biomarkers, Proteomics, Proteomics clin appl, Randomised trials, Recherche medicale, Regulatory agencies, Renal, Renal disease, Research centre, Research priorities, Siriraj hospital, Stanford, Stanford university school, Stichting european society, Successful biomarker discovery, Successful implementation, Surrogate, Surrogate endpoints, Surrogate parameter, Swedish university, Therapeutic intervention, Uncertain path, Universitatsklinikum mannheim, Universite toulouse, Uppsala university, Urine proteomics cost action, Useful biomarkers, Valid biomarkers, Validation, Validation processes.
Abstract
Eur J Clin Invest 2012; 42 (9): 1027–1036
Url:
- https://api.istex.fr/document/6C88B9F7C98EEE2B3A0A46F5A01B94C1FC4089F2/fulltext/pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3464367
DOI: 10.1111/j.1365-2362.2012.02674.x
Affiliations:
- Allemagne, Australie, Autriche, Belgique, Danemark, Espagne, France, Grèce, Italie, Macédoine (pays), Pays-Bas, Royaume-Uni, Suède, Thaïlande, États-Unis
- Alabama, Angleterre, Attique (région), Bade-Wurtemberg, Basse-Saxe, Berlin, Californie, Colorado, Communauté de Madrid, District de Karlsruhe, East Middle Sweden, Grand Londres, Grand Manchester, Groningue (province), Illinois, Midi-Pyrénées, Occitanie (région administrative), Région de Bruxelles-Capitale, Svealand, Tyrol (Land), Écosse
- Athènes, Berlin, Bruxelles, Glasgow, Groningue, Hanovre, Innsbruck, Londres, Madrid, Manchester, Mannheim, Toulouse, Uppsala
- Université d'Uppsala, Université de Glasgow, Université de Manchester, Université de médecine d'Innsbruck
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Le document en format XML
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Attwood</name><affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Faculty of Life Sciences and School of Computer Science, University of Manchester, Manchester</wicri:regionArea><placeName><settlement type="city">Manchester</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Manchester</region><settlement type="city">Manchester</settlement></placeName><orgName type="university">Université de Manchester</orgName></affiliation></author><author><name sortKey="Bongcam Udloff, Erik" sort="Bongcam Udloff, Erik" uniqKey="Bongcam Udloff E" first="Erik" last="Bongcam-Rudloff">Erik Bongcam-Rudloff</name><affiliation wicri:level="4"><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala</wicri:regionArea><wicri:noRegion>Uppsala</wicri:noRegion></affiliation></author><author><name sortKey="Broenstrup, Mark" sort="Broenstrup, Mark" uniqKey="Broenstrup M" first="Mark" last="Broenstrup">Mark Broenstrup</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Sanofi‐Aventis Deutschland GmbH D‐65926 Frankfurt am Main</wicri:regionArea></affiliation></author><author><name sortKey="Charonis, Aristidis" sort="Charonis, Aristidis" uniqKey="Charonis A" first="Aristidis" last="Charonis">Aristidis Charonis</name><affiliation wicri:level="3"><country xml:lang="fr">Grèce</country><wicri:regionArea>Divisions of Histology and Biotechnology, Biomedical Research Foundation, Academy of Athens, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Chrousos, George P" sort="Chrousos, George P" uniqKey="Chrousos G" first="George P" last="Chrousos">George P. Chrousos</name><affiliation wicri:level="3"><country xml:lang="fr">Grèce</country><wicri:regionArea>First Department of Pediatrics, Athens University Medical School, Aghia Sophia Children’s Hospital, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Delles, Christian" sort="Delles, Christian" uniqKey="Delles C" first="Christian" last="Delles">Christian Delles</name><affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow</wicri:regionArea><orgName type="university">Université de Glasgow</orgName><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Dominiczak, Anna" sort="Dominiczak, Anna" uniqKey="Dominiczak A" first="Anna" last="Dominiczak">Anna Dominiczak</name><affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow</wicri:regionArea><orgName type="university">Université de Glasgow</orgName><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Dylag, Tomasz" sort="Dylag, Tomasz" uniqKey="Dylag T" first="Tomasz" last="Dylag">Tomasz Dylag</name><affiliation wicri:level="3"><country xml:lang="fr">Belgique</country><wicri:regionArea>European Commission, Directorate‐General for Research and Innovation, Unit F5: Personalised Medicine, 21 rue du Champ de Mars, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Ehrich, Jochen" sort="Ehrich, Jochen" uniqKey="Ehrich J" first="Jochen" last="Ehrich">Jochen Ehrich</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Hannover Medical School, Department of Pediatrics, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Egido, Jesus" sort="Egido, Jesus" uniqKey="Egido J" first="Jesus" last="Egido">Jesus Egido</name><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>IIS‐Fundación Jiménez Díaz, Autonoma University, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Findeisen, Peter" sort="Findeisen, Peter" uniqKey="Findeisen P" first="Peter" last="Findeisen">Peter Findeisen</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>C Institute of Clinical Chemistry, Universitätsklinikum Mannheim, Mannheim</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Mannheim</settlement></placeName></affiliation></author><author><name sortKey="Jankowski, Joachim" sort="Jankowski, Joachim" uniqKey="Jankowski J" first="Joachim" last="Jankowski">Joachim Jankowski</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Charité (CBF), Medizinische Klinik IV, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Johnson, Robert W" sort="Johnson, Robert W" uniqKey="Johnson R" first="Robert W." last="Johnson">Robert W. Johnson</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Abbott Laboratories, Abbott Park, IL</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Julien, Bruce A" sort="Julien, Bruce A" uniqKey="Julien B" first="Bruce A." last="Julien">Bruce A. Julien</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, University of Alabama at Birmingham, Birmingham, AL</wicri:regionArea><placeName><region type="state">Alabama</region></placeName></affiliation></author><author><name sortKey="Lankisch, Tim" sort="Lankisch, Tim" uniqKey="Lankisch T" first="Tim" last="Lankisch">Tim Lankisch</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Leung, Hing Y" sort="Leung, Hing Y" uniqKey="Leung H" first="Hing Y." last="Leung">Hing Y. Leung</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Beatson Institute for Cancer Research, Garscube Estate, Glasgow</wicri:regionArea><wicri:noRegion>Glasgow</wicri:noRegion></affiliation></author><author><name sortKey="Maahs, David" sort="Maahs, David" uniqKey="Maahs D" first="David" last="Maahs">David Maahs</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Magni, Fulvio" sort="Magni, Fulvio" uniqKey="Magni F" first="Fulvio" last="Magni">Fulvio Magni</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Experimental Medicine, University of Milano‐Bicocca, Monza</wicri:regionArea><wicri:noRegion>Monza</wicri:noRegion></affiliation></author><author><name sortKey="Manns, Michael P" sort="Manns, Michael P" uniqKey="Manns M" first="Michael P." last="Manns">Michael P. Manns</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Manolis, Efthymios" sort="Manolis, Efthymios" uniqKey="Manolis E" first="Efthymios" last="Manolis">Efthymios Manolis</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>European Medicines Agency, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Mayer, Gert" sort="Mayer, Gert" uniqKey="Mayer G" first="Gert" last="Mayer">Gert Mayer</name><affiliation wicri:level="4"><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Internal Medicine IV, Medical University of Innsbruck, Innsbruck</wicri:regionArea><orgName type="university">Université de médecine d'Innsbruck</orgName><placeName><settlement type="city">Innsbruck</settlement><region nuts="2" type="region">Tyrol (Land)</region></placeName></affiliation></author><author><name sortKey="Navis, Gerjan" sort="Navis, Gerjan" uniqKey="Navis G" first="Gerjan" last="Navis">Gerjan Navis</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Division of Nephrology, Department of Internal Medicine, University Medical Centre Groningen, University of Groningen, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Novak, Jan" sort="Novak, Jan" uniqKey="Novak J" first="Jan" last="Novak">Jan Novak</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL</wicri:regionArea><placeName><region type="state">Alabama</region></placeName></affiliation></author><author><name sortKey="Ortiz, Alberto" sort="Ortiz, Alberto" uniqKey="Ortiz A" first="Alberto" last="Ortiz">Alberto Ortiz</name><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>IIS‐Fundación Jiménez Díaz, Autonoma University, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Persson, Frederik" sort="Persson, Frederik" uniqKey="Persson F" first="Frederik" last="Persson">Frederik Persson</name><affiliation wicri:level="1"><country xml:lang="fr">Danemark</country><wicri:regionArea>Steno Diabetes Center, Gentofte</wicri:regionArea><wicri:noRegion>Gentofte</wicri:noRegion></affiliation></author><author><name sortKey="Peter, Karlheinz" sort="Peter, Karlheinz" uniqKey="Peter K" first="Karlheinz" last="Peter">Karlheinz Peter</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Baker Heart Research Institute, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Riese, Hans H" sort="Riese, Hans H" uniqKey="Riese H" first="Hans H." last="Riese">Hans H. Riese</name><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>European Projects Office, Institute of Health Carlos III, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Rossing, Peter" sort="Rossing, Peter" uniqKey="Rossing P" first="Peter" last="Rossing">Peter Rossing</name><affiliation wicri:level="1"><country xml:lang="fr">Danemark</country><wicri:regionArea>Steno Diabetes Center, Gentofte</wicri:regionArea><wicri:noRegion>Gentofte</wicri:noRegion></affiliation></author><author><name sortKey="Sattar, Naveed" sort="Sattar, Naveed" uniqKey="Sattar N" first="Naveed" last="Sattar">Naveed Sattar</name><affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow</wicri:regionArea><orgName type="university">Université de Glasgow</orgName><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Spasovski, Goce" sort="Spasovski, Goce" uniqKey="Spasovski G" first="Goce" last="Spasovski">Goce Spasovski</name><affiliation wicri:level="1"><country xml:lang="fr">Macédoine (pays)</country><wicri:regionArea>Department of Nephrology, Medical Faculty, University of Skopje, Skopje</wicri:regionArea><wicri:noRegion>Skopje</wicri:noRegion></affiliation></author><author><name sortKey="Thongboonkerd, Visith" sort="Thongboonkerd, Visith" uniqKey="Thongboonkerd V" first="Visith" last="Thongboonkerd">Visith Thongboonkerd</name><affiliation wicri:level="1"><country xml:lang="fr">Thaïlande</country><wicri:regionArea>Faculty of Medicine at Siriraj Hospital, Mahidol University, Bangkok</wicri:regionArea><wicri:noRegion>Bangkok</wicri:noRegion></affiliation></author><author><name sortKey="Vanholder, Raymond" sort="Vanholder, Raymond" uniqKey="Vanholder R" first="Raymond" last="Vanholder">Raymond Vanholder</name><affiliation wicri:level="1"><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Nephrology, Ghent University Hospital, Ghent</wicri:regionArea><wicri:noRegion>Ghent</wicri:noRegion></affiliation></author><author><name sortKey="Schanstra, Joost P" sort="Schanstra, Joost P" uniqKey="Schanstra J" first="Joost P." last="Schanstra">Joost P. Schanstra</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé et de la Recherche Médicale (INSERM), U1048, Institut of Cardiovascular and Metabolic Disease and Université Toulouse III Paul‐Sabatier,Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Vlahou, Antonia" sort="Vlahou, Antonia" uniqKey="Vlahou A" first="Antonia" last="Vlahou">Antonia Vlahou</name><affiliation wicri:level="1"><country xml:lang="fr">Grèce</country><wicri:regionArea>Division of Biotechnology, Biomedical Research Foundation, Academy of Athens, 11527 Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">European Journal of Clinical Investigation</title><title level="j" type="alt">EUROPEAN JOURNAL OF CLINICAL INVESTIGATION</title><idno type="ISSN">0014-2972</idno><idno type="eISSN">1365-2362</idno><imprint><biblScope unit="vol">42</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="1027">1027</biblScope><biblScope unit="page" to="1036">1036</biblScope><biblScope unit="page-count">10</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2012-09">2012-09</date></imprint><idno type="ISSN">0014-2972</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0014-2972</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Abbott park</term><term>Actual implementation</term><term>Aghia sophia hospital</term><term>Agricultural sciences</term><term>Appl</term><term>Appropriate specimens</term><term>Athens university</term><term>Beatson institute</term><term>Biobanks</term><term>Biomarker</term><term>Biomarker community</term><term>Biomarker discovery</term><term>Biomarker evaluation</term><term>Biomarkers</term><term>Biomedical research foundation</term><term>Cancer biomarkers</term><term>Cancer research</term><term>Cell proteomics</term><term>Centre groningen</term><term>Childhood diabetes</term><term>Chronic kidney disease</term><term>Clin</term><term>Clin cancer</term><term>Clin chem</term><term>Clinical adoption</term><term>Clinical application</term><term>Clinical chemistry</term><term>Clinical implementation</term><term>Clinical investigation</term><term>Clinical investigation journal foundation implementation</term><term>Clinical proteomics</term><term>Clinical trials</term><term>Clinical validity</term><term>Collaborative projects</term><term>Colorado denver</term><term>Computer science</term><term>Current situation</term><term>Data analysis</term><term>Deutschland gmbh frankfurt</term><term>Diabetes</term><term>Diabetes mellitus</term><term>Diabetic nephropathy</term><term>Different categories</term><term>Drug development</term><term>Early detection research network</term><term>Early prevention</term><term>Endpoint</term><term>European biobanks</term><term>European commission</term><term>European journal</term><term>European kidney</term><term>European medicines agency</term><term>Everyday practice</term><term>Experimental medicine</term><term>Foreseeable future</term><term>Former yugoslav republic</term><term>Funding</term><term>Garscube estate</term><term>Ghent university hospital</term><term>Glasgow</term><term>Hannover</term><term>Hard endpoint</term><term>Hard endpoints</term><term>Health carlos</term><term>Health economists</term><term>Health insurance</term><term>Health research</term><term>Implementation</term><term>Implementation process</term><term>Initial discovery</term><term>Internal medicine</term><term>Intervention study</term><term>Interventional trials</term><term>Ioannidis</term><term>Ioannina school</term><term>Jimenez autonoma university</term><term>Last decade</term><term>Life sciences</term><term>Mahidol university</term><term>Many years</term><term>Medical faculty</term><term>Medical practice</term><term>Medical sciences</term><term>Medical university</term><term>Medizinische klinik</term><term>Metabolic disease</term><term>Microvascular outcomes</term><term>Mischak</term><term>Molecular epidemiology unit</term><term>Montpellier cedex</term><term>Multidisciplinary panel</term><term>Natl cancer inst</term><term>Ndings</term><term>Patient groups</term><term>Performance characteristics</term><term>Personalised medicine</term><term>Possible solutions</term><term>Proteomic</term><term>Proteomic biomarkers</term><term>Proteomics</term><term>Proteomics clin appl</term><term>Randomised trials</term><term>Recherche medicale</term><term>Regulatory agencies</term><term>Renal</term><term>Renal disease</term><term>Research centre</term><term>Research priorities</term><term>Siriraj hospital</term><term>Stanford</term><term>Stanford university school</term><term>Stichting european society</term><term>Successful biomarker discovery</term><term>Successful implementation</term><term>Surrogate</term><term>Surrogate endpoints</term><term>Surrogate parameter</term><term>Swedish university</term><term>Therapeutic intervention</term><term>Uncertain path</term><term>Universitatsklinikum mannheim</term><term>Universite toulouse</term><term>Uppsala university</term><term>Urine proteomics cost action</term><term>Useful biomarkers</term><term>Valid biomarkers</term><term>Validation</term><term>Validation processes</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Abbott park</term><term>Actual implementation</term><term>Aghia sophia hospital</term><term>Agricultural sciences</term><term>Appl</term><term>Appropriate specimens</term><term>Athens university</term><term>Beatson institute</term><term>Biobanks</term><term>Biomarker</term><term>Biomarker community</term><term>Biomarker discovery</term><term>Biomarker evaluation</term><term>Biomarkers</term><term>Biomedical research foundation</term><term>Cancer biomarkers</term><term>Cancer research</term><term>Cell proteomics</term><term>Centre groningen</term><term>Childhood diabetes</term><term>Chronic kidney disease</term><term>Clin</term><term>Clin cancer</term><term>Clin chem</term><term>Clinical adoption</term><term>Clinical application</term><term>Clinical chemistry</term><term>Clinical implementation</term><term>Clinical investigation</term><term>Clinical investigation journal foundation implementation</term><term>Clinical proteomics</term><term>Clinical trials</term><term>Clinical validity</term><term>Collaborative projects</term><term>Colorado denver</term><term>Computer science</term><term>Current situation</term><term>Data analysis</term><term>Deutschland gmbh frankfurt</term><term>Diabetes</term><term>Diabetes mellitus</term><term>Diabetic nephropathy</term><term>Different categories</term><term>Drug development</term><term>Early detection research network</term><term>Early prevention</term><term>Endpoint</term><term>European biobanks</term><term>European commission</term><term>European journal</term><term>European kidney</term><term>European medicines agency</term><term>Everyday practice</term><term>Experimental medicine</term><term>Foreseeable future</term><term>Former yugoslav republic</term><term>Funding</term><term>Garscube estate</term><term>Ghent university hospital</term><term>Glasgow</term><term>Hannover</term><term>Hard endpoint</term><term>Hard endpoints</term><term>Health carlos</term><term>Health economists</term><term>Health insurance</term><term>Health research</term><term>Implementation</term><term>Implementation process</term><term>Initial discovery</term><term>Internal medicine</term><term>Intervention study</term><term>Interventional trials</term><term>Ioannidis</term><term>Ioannina school</term><term>Jimenez autonoma university</term><term>Last decade</term><term>Life sciences</term><term>Mahidol university</term><term>Many years</term><term>Medical faculty</term><term>Medical practice</term><term>Medical sciences</term><term>Medical university</term><term>Medizinische klinik</term><term>Metabolic disease</term><term>Microvascular outcomes</term><term>Mischak</term><term>Molecular epidemiology unit</term><term>Montpellier cedex</term><term>Multidisciplinary panel</term><term>Natl cancer inst</term><term>Ndings</term><term>Patient groups</term><term>Performance characteristics</term><term>Personalised medicine</term><term>Possible solutions</term><term>Proteomic</term><term>Proteomic biomarkers</term><term>Proteomics</term><term>Proteomics clin appl</term><term>Randomised trials</term><term>Recherche medicale</term><term>Regulatory agencies</term><term>Renal</term><term>Renal disease</term><term>Research centre</term><term>Research priorities</term><term>Siriraj hospital</term><term>Stanford</term><term>Stanford university school</term><term>Stichting european society</term><term>Successful biomarker discovery</term><term>Successful implementation</term><term>Surrogate</term><term>Surrogate endpoints</term><term>Surrogate parameter</term><term>Swedish university</term><term>Therapeutic intervention</term><term>Uncertain path</term><term>Universitatsklinikum mannheim</term><term>Universite toulouse</term><term>Uppsala university</term><term>Urine proteomics cost action</term><term>Useful biomarkers</term><term>Valid biomarkers</term><term>Validation</term><term>Validation processes</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Diabète</term><term>Assurance maladie</term><term>Sciences de la vie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">Eur J Clin Invest 2012; 42 (9): 1027–1036</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Autriche</li><li>Belgique</li><li>Danemark</li><li>Espagne</li><li>France</li><li>Grèce</li><li>Italie</li><li>Macédoine (pays)</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>Suède</li><li>Thaïlande</li><li>États-Unis</li></country><region><li>Alabama</li><li>Angleterre</li><li>Attique (région)</li><li>Bade-Wurtemberg</li><li>Basse-Saxe</li><li>Berlin</li><li>Californie</li><li>Colorado</li><li>Communauté de Madrid</li><li>District de Karlsruhe</li><li>East Middle Sweden</li><li>Grand Londres</li><li>Grand Manchester</li><li>Groningue (province)</li><li>Illinois</li><li>Midi-Pyrénées</li><li>Occitanie (région administrative)</li><li>Région de Bruxelles-Capitale</li><li>Svealand</li><li>Tyrol (Land)</li><li>Écosse</li></region><settlement><li>Athènes</li><li>Berlin</li><li>Bruxelles</li><li>Glasgow</li><li>Groningue</li><li>Hanovre</li><li>Innsbruck</li><li>Londres</li><li>Madrid</li><li>Manchester</li><li>Mannheim</li><li>Toulouse</li><li>Uppsala</li></settlement><orgName><li>Université d'Uppsala</li><li>Université de Glasgow</li><li>Université de Manchester</li><li>Université de médecine d'Innsbruck</li></orgName></list><tree><country name="Royaume-Uni"><region name="Écosse"><name sortKey="Mischak, Harald" sort="Mischak, Harald" uniqKey="Mischak H" first="Harald" last="Mischak">Harald Mischak</name></region><name sortKey="Attwood, Teresa K" sort="Attwood, Teresa K" uniqKey="Attwood T" first="Teresa K." last="Attwood">Teresa K. Attwood</name><name sortKey="Delles, Christian" sort="Delles, Christian" uniqKey="Delles C" first="Christian" last="Delles">Christian Delles</name><name sortKey="Dominiczak, Anna" sort="Dominiczak, Anna" uniqKey="Dominiczak A" first="Anna" last="Dominiczak">Anna Dominiczak</name><name sortKey="Leung, Hing Y" sort="Leung, Hing Y" uniqKey="Leung H" first="Hing Y." last="Leung">Hing Y. Leung</name><name sortKey="Manolis, Efthymios" sort="Manolis, Efthymios" uniqKey="Manolis E" first="Efthymios" last="Manolis">Efthymios Manolis</name><name sortKey="Sattar, Naveed" sort="Sattar, Naveed" uniqKey="Sattar N" first="Naveed" last="Sattar">Naveed Sattar</name></country><country name="Allemagne"><region name="Basse-Saxe"><name sortKey="Mischak, Harald" sort="Mischak, Harald" uniqKey="Mischak H" first="Harald" last="Mischak">Harald Mischak</name></region><name sortKey="Broenstrup, Mark" sort="Broenstrup, Mark" uniqKey="Broenstrup M" first="Mark" last="Broenstrup">Mark Broenstrup</name><name sortKey="Ehrich, Jochen" sort="Ehrich, Jochen" uniqKey="Ehrich J" first="Jochen" last="Ehrich">Jochen Ehrich</name><name sortKey="Findeisen, Peter" sort="Findeisen, Peter" uniqKey="Findeisen P" first="Peter" last="Findeisen">Peter Findeisen</name><name sortKey="Jankowski, Joachim" sort="Jankowski, Joachim" uniqKey="Jankowski J" first="Joachim" last="Jankowski">Joachim Jankowski</name><name sortKey="Lankisch, Tim" sort="Lankisch, Tim" uniqKey="Lankisch T" first="Tim" last="Lankisch">Tim Lankisch</name><name sortKey="Manns, Michael P" sort="Manns, Michael P" uniqKey="Manns M" first="Michael P." last="Manns">Michael P. Manns</name></country><country name="Grèce"><noRegion><name sortKey="Ioannidis, John P A" sort="Ioannidis, John P A" uniqKey="Ioannidis J" first="John P. A." last="Ioannidis">John P. A. Ioannidis</name></noRegion><name sortKey="Charonis, Aristidis" sort="Charonis, Aristidis" uniqKey="Charonis A" first="Aristidis" last="Charonis">Aristidis Charonis</name><name sortKey="Chrousos, George P" sort="Chrousos, George P" uniqKey="Chrousos G" first="George P" last="Chrousos">George P. Chrousos</name><name sortKey="Vlahou, Antonia" sort="Vlahou, Antonia" uniqKey="Vlahou A" first="Antonia" last="Vlahou">Antonia Vlahou</name></country><country name="États-Unis"><region name="Californie"><name sortKey="Ioannidis, John P A" sort="Ioannidis, John P A" uniqKey="Ioannidis J" first="John P. A." last="Ioannidis">John P. A. Ioannidis</name></region><name sortKey="Ioannidis, John P A" sort="Ioannidis, John P A" uniqKey="Ioannidis J" first="John P. A." last="Ioannidis">John P. A. Ioannidis</name><name sortKey="Ioannidis, John P A" sort="Ioannidis, John P A" uniqKey="Ioannidis J" first="John P. A." last="Ioannidis">John P. A. Ioannidis</name><name sortKey="Johnson, Robert W" sort="Johnson, Robert W" uniqKey="Johnson R" first="Robert W." last="Johnson">Robert W. Johnson</name><name sortKey="Julien, Bruce A" sort="Julien, Bruce A" uniqKey="Julien B" first="Bruce A." last="Julien">Bruce A. Julien</name><name sortKey="Maahs, David" sort="Maahs, David" uniqKey="Maahs D" first="David" last="Maahs">David Maahs</name><name sortKey="Novak, Jan" sort="Novak, Jan" uniqKey="Novak J" first="Jan" last="Novak">Jan Novak</name></country><country name="France"><noRegion><name sortKey="Argiles, Angel" sort="Argiles, Angel" uniqKey="Argiles A" first="Angel" last="Argiles">Angel Argiles</name></noRegion><name sortKey="Schanstra, Joost P" sort="Schanstra, Joost P" uniqKey="Schanstra J" first="Joost P." last="Schanstra">Joost P. Schanstra</name></country><country name="Suède"><region name="Svealand"><name sortKey="Bongcam Udloff, Erik" sort="Bongcam Udloff, Erik" uniqKey="Bongcam Udloff E" first="Erik" last="Bongcam-Rudloff">Erik Bongcam-Rudloff</name></region><name sortKey="Bongcam Udloff, Erik" sort="Bongcam Udloff, Erik" uniqKey="Bongcam Udloff E" first="Erik" last="Bongcam-Rudloff">Erik Bongcam-Rudloff</name></country><country name="Belgique"><region name="Région de Bruxelles-Capitale"><name sortKey="Dylag, Tomasz" sort="Dylag, Tomasz" uniqKey="Dylag T" first="Tomasz" last="Dylag">Tomasz Dylag</name></region><name sortKey="Vanholder, Raymond" sort="Vanholder, Raymond" uniqKey="Vanholder R" first="Raymond" last="Vanholder">Raymond Vanholder</name></country><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Egido, Jesus" sort="Egido, Jesus" uniqKey="Egido J" first="Jesus" last="Egido">Jesus Egido</name></region><name sortKey="Ortiz, Alberto" sort="Ortiz, Alberto" uniqKey="Ortiz A" first="Alberto" last="Ortiz">Alberto Ortiz</name><name sortKey="Riese, Hans H" sort="Riese, Hans H" uniqKey="Riese H" first="Hans H." last="Riese">Hans H. Riese</name></country><country name="Italie"><noRegion><name sortKey="Magni, Fulvio" sort="Magni, Fulvio" uniqKey="Magni F" first="Fulvio" last="Magni">Fulvio Magni</name></noRegion></country><country name="Autriche"><region name="Tyrol (Land)"><name sortKey="Mayer, Gert" sort="Mayer, Gert" uniqKey="Mayer G" first="Gert" last="Mayer">Gert Mayer</name></region></country><country name="Pays-Bas"><region name="Groningue (province)"><name sortKey="Navis, Gerjan" sort="Navis, Gerjan" uniqKey="Navis G" first="Gerjan" last="Navis">Gerjan Navis</name></region></country><country name="Danemark"><noRegion><name sortKey="Persson, Frederik" sort="Persson, Frederik" uniqKey="Persson F" first="Frederik" last="Persson">Frederik Persson</name></noRegion><name sortKey="Rossing, Peter" sort="Rossing, Peter" uniqKey="Rossing P" first="Peter" last="Rossing">Peter Rossing</name></country><country name="Australie"><noRegion><name sortKey="Peter, Karlheinz" sort="Peter, Karlheinz" uniqKey="Peter K" first="Karlheinz" last="Peter">Karlheinz Peter</name></noRegion></country><country name="Macédoine (pays)"><noRegion><name sortKey="Spasovski, Goce" sort="Spasovski, Goce" uniqKey="Spasovski G" first="Goce" last="Spasovski">Goce Spasovski</name></noRegion></country><country name="Thaïlande"><noRegion><name sortKey="Thongboonkerd, Visith" sort="Thongboonkerd, Visith" uniqKey="Thongboonkerd V" first="Visith" last="Thongboonkerd">Visith Thongboonkerd</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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